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. 2022 Sep 16;13:986802. doi: 10.3389/fphar.2022.986802

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Copyright © 2022 Ahsan, Mushtaq, Saleem, Malik, Sarfaraz, Shahzad, Uhlin and Ahmad.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Time kill curve demonstrating in vitro efficacy of doxycycline in colistin resistant clinical isolate AB-4 (A) Kill curve of AB-4 upon the treatment with different concentrations of doxycycline. The MIC value for doxycycline in AB-4 is 0.5 ug/ml (B) Kill curve of A. baumannii 17978 (AB17978 upon the treatment with different concentrations of doxycycline. The MIC value for doxycycline in AB17978 is 0.125 ug/ml (C) Kill curve of AB-4 upon the treatment with different concentrations of colistin. The MIC value for colistin in AB-4 is 16 ug/ml (D) Kill curve of AB-4 upon the treatment with colistin and doxycycline. Bars show mean ± standard deviation from at least five independent biological experiments.