Table 3. ICC of Regional Brain Volume Measured by the Three Software Programs in the Total Study Population.

		DB vs. FS		NQ vs. FS		DB vs. NQ
		Lt. Hemisphere	Rt. Hemisphere	Lt. Hemisphere	Rt. Hemisphere	Lt. Hemisphere	Rt. Hemisphere
Cortical GM
	SMC	0.93 (0.03–0.98)	0.93 (0.03–0.98)	0.45 (-0.02–0.80)	0.42 (-0.02–0.78)	0.35 (-0.02–0.72)	0.33 (-0.02–0.71)
	ADNI	0.93 (0.28–0.98)	0.90 (0.12–0.97)	0.71 (-0.06–0.92)	0.70 (-0.06–0.91)	0.57 (-0.05–0.86)	0.53 (-0.05–0.84)
Caudate
	SMC	0.88 (0.66–0.94)	0.74 (0.07–0.90)	0.44 (-0.08–0.77)	0.55 (-0.09–0.82)	0.40 (-0.04–0.76)	0.38 (-0.05–0.74)
	ADNI	0.81 (0.41–0.92)	0.86 (0.40–0.95)	0.62 (-0.05–0.85)	0.59 (-0.07–0.83)	0.45 (-0.09–0.77)	0.48 (-0.07–0.80)
Putamen
	SMC	0.52(-0.05–0.83)	0.65 (-0.07–0.89)	0.72 (-0.02–0.90)	0.78 (0.45–0.89)	0.78 (0.04–0.92)	0.77 (0.23–0.90)
	ADNI	0.35(-0.04–0.72)	0.50 (-0.04–0.82)	0.36 (-0.09–0.70)	0.46 (-0.09–0.76)	0.72 (0.61–0.80)	0.68 (0.57–0.76)
Pallidum
	SMC	0.15(-0.04–0.46)	0.18 (-0.04–0.50)	0.01 (-0.01–0.07)	0.01 (-0.01–0.05)	0.04 (-0.03–0.17)	0.04 (-0.02–0.17)
	ADNI	0.21(-0.07–0.52)	0.23 (-0.06–0.58)	0.01 (-0.01–0.03)	0.004 (-0.01–0.02)	0.01 (-0.01–0.04)	0.01 (-0.01–0.04)
Thalamus
	SMC	0.74(-0.06–0.92)	0.93 (0.90–0.95)	0.65 (-0.06–0.87)	0.67 (-0.07–0.89)	0.85 (0.80–0.89)	0.65 (-0.05–0.86)
	ADNI	0.70 (0.02–0.88)	0.83 (0.64–0.91)	0.47 (-0.10–0.76)	0.44 (-0.08–0.72)	0.65 (0.37–0.80)	0.48 (0.01–0.72)
Amygdala
	SMC	0.83 (0.74–0.89)	0.88 (0.83–0.92)	0.82 (0.53–0.91)	0.83 (0.68–0.90)	0.87 (0.77–0.92)	0.81 (0.12–0.93)
	ADNI	0.77 (0.12–0.91)	0.87 (0.77–0.92)	0.77 (-0.02–0.93)	0.86 (0.72–0.92)	0.89 (0.84–0.92)	0.79 (0.19–0.92)
	Hippocampus
	SMC	0.84 (0.05–0.95)	0.81 (-0.05–0.95)	0.82 (0.50–0.92)	0.83 (0.37–0.93)	0.72 (-0.05–0.92)	0.63 (-0.06–0.88)
	ADNI	0.86 (0.29–0.95)	0.84 (0.28–0.94)	0.75 (-0.03–0.91)	0.69 (-0.02–0.88)	0.60 (-0.07–0.87)	0.55 (-0.08–0.84)
Cerebellum
	SMC	0.81 (-0.05–0.95)	0.84 (0.16–0.95)	0.93 (0.67–0.97)	0.93 (0.85–0.97)	0.70 (-0.04–0.92)	0.78 (-0.05–0.94)
	ADNI	0.73 (-0.06–0.92)	0.81 (-0.05–0.95)	0.89 (0.65–0.95)	0.88 (0.53–0.95)	0.85 (0.05–0.96)	0.91 (0.68–0.96)
Total cortical GM
	SMC	0.93 (0.02–0.98)		0.43 (-0.02–0.79)		0.34 (-0.02–0.71)
	ADNI	0.92 (0.16–0.98)		0.70 (-0.06–0.91)		0.54 (-0.05–0.85)
Total cerebral WM
	SMC	0.97 (0.77–0.99)		0.90 (0.06–0.97)		0.96 (0.57–0.99)
	ADNI	0.93 (0.80–0.96)		0.79 (0.67–0.86)		0.81 (0.74–0.86)
TICV
	SMC	0.51 (-0.04–0.83)		0.93 (0.91–0.95)		0.50 (-0.02–0.83)
	ADNI	0.86 (0.75–0.92)		0.88 (0.83–0.91)		0.82 (0.66–0.89)

Data are ICC (95% confidence interval). AD = Alzheimer’s disease, ADNI = Alzheimer’s Disease Neuroimaging Initiative, DB = DeepBrain, FS = FreeSurfer, GM = gray matter, ICC = intraclass correlation coefficient, MCI = mild cognitive impairment, NL = normal elderly participants, NQ = NeuroQuant, SMC = single medical center, TICV = total intracranial volume, WM = white matter