Skip to main content
. 2022 Sep 13;25(10):105135. doi: 10.1016/j.isci.2022.105135

Figure 1.

Figure 1

Peroxisome dysfunction may play an important role in the fatty liver

(A) Gene set analysis of GSE33814 (19 steatosis patient liver tissues vs. 13 normal patient liver tissues) and GSE39549 (3 HFD mouse liver vs. 3 NCD mouse liver).

(B) Analysis of peroxisomal genes in GSE39549 (liver of HFD mice vs. NCD mice) and the expression level of Nudt7 in GSE39549 (n = 3).

(C) Representative images of NUDT7 staining in HFD liver compared to NCD liver (n = 4). Scale bars, 100 μm.

(D) Expression level of peroxisomal genes of Cat+/+ and Cat−/− mouse liver using qRT-PCR (n = 3).

(E) Expression level of peroxisomal genes with shCon or shAcox1 lentivirus-injected mouse liver using qRT-PCR (n = 4) and analyzed of peroxisomal genes in GSE39549 and GSE49541. Values were expressed as means + SD An unpaired t-test was used for statistical analysis. ns = non-significant, ∗p ≤ 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001.