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. 2022 Sep 13;25(10):105135. doi: 10.1016/j.isci.2022.105135

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© 2022 The Author(s)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Nudt7^+/− mice display typical characteristics of fatty liver

(A) Representative images of liver, H&E, Oil Red O, and Filipin staining in Nudt7^+/+ and Nudt7^+/− mouse liver (n = 4).

(B) Food and water intake (n = 6), body and liver per body weight (n = 4).

(C) Analysis of blood glucose level (left panel) in Nudt7^+/+ (n = 4) and Nudt7^+/− (n = 4) mouse and serum AST and ALT, hepatic FFA and TG level (n = 4).

(D) Oxygen consumption (VO₂), CO₂ production (VCO₂), and heat production were analyzed (n = 5).

(E) RNA sequencing data of 12-month-old Nudt7^+/+ and Nudt7^+/− liver were analyzed using KEGG pathway enrichment analysis (n = 3).

(F) Gene set analysis of Nudt7^+/+ and Nudt7^+/− mouse liver. ns = non-significant, ∗p ≤ 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001, ∗∗∗∗p < 0.0001 (Unpaired t-test or two-way ANOVA).