REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
ACOX1	Cusabio	Cat# PA617998HA01HU
H3K4me3	Abcam	Cat# ab8580; RRID:AB_306649
NUDT7	Youngin Frontier	N/A
PPARγ	Abcam	Cat# ab41928; RRID:AB_777392
FABP4	Abcam	Cat# ab92501; RRID:AB_10562486
FASN	Cell signaling technology	Cat# 3180S; RRID:AB_2100796
PMP70	Abcam	Cat# ab211533
SCD1	Abcam	Cat# ab19862; RRID:AB_445179
H3K4me2	Cell signaling technology	Cat#9725; RRID:AB_10205451
H3K27me2	Cell signaling technology	Cat#9755; RRID:AB_659841
H3K27me3	Abcam	Cat#ab6002; RRID:AB_305237
Histone H3	Cell signaling technology	Cat#4499; RRID:AB_10544537
Chemicals, peptides, and recombinant proteins
CellMask™ Orange Plasma membrane Stain	Thermo Fisher Scientific	C10045
Oil red O	Sigma-Aldrich	Cat# O0625s
BODIPY493/503	Thermo Fisher Scientific	Cat# D3922
BODIPY581/591	Thermo Fisher Scientific	Cat# D3861
Filipin	Sigma-Aldrich	Cat# SAE0088
3rd generation packaging system	ABM	Cat# LV053
Lentifectin	ABM	Cat# G074
Lenti-X Concentrator	Clontech	Cat# PT4421-2
Critical commercial assays
Nuclear/Cytosol Extraction Kit	BioVision	K266-100
EZ-Triglyceride Quantification Assay Kit	DoGen	Cat# DG-TGC100
EZ-Free Fatty Acid Assay Kit	DoGen	Cat # DG-FFA100
EZ-Total Cholesterol Assay Kit	DoGen	Cat# DG-TSC100
Quick Cell Proliferation Colorimetric Assay Kit	BioVision	Cat# K302-2500
Catalase Activity Colorimetric/Fluorometric Assay Kit	BioVision	Cat# K773-100
ChIP-IT Express Kit	Active Motif	Cat# 53009
Experimental models: Cell lines
HEK-293T	ATCC	CRL-3216
Hepatocyte	This paper	N/A
Experimental models: Organisms/strains
Mouse: Nudt7+/−: C57BL/6N	Song et al. (2018, NComm)	N/A
Mouse: Catalse−/−: C57BL/6N	Generously donated by Goo Taeg Oh, Ewha Womans University	N/A
Oligonucleotides
See Table S2 for primer sequences.
Software and algorithms
RStudio	RStudio	https://github.com/rstudio/rstudio
QIAGEN’s Ingenuity Pathway Analysis algorithm (IPA)	QIAGEN	www.qiagen.com/ingenuity
Gene Set Enrichment Analysis (GSEA)	Subramanian, Tamayo, et al. (2005, PNAS) and and Mootha, Lindgren, et al. (2003, Nature Genetics)	www.gsea-msigdb.org/gsea