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. 2022 Sep 16;13:1014744. doi: 10.3389/fphys.2022.1014744

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Copyright © 2022 Tu, Qian, Zhang, Barksdale, Wadman, Pipinos and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pathological alterations of gastrocnemius muscles induced by 6 weeks of the femoral artery ligation (Isch) in C57BL/6 and BALB/c mice. (A), representative histological images of the longitudinal muscle section with Masson’s trichrome staining. (B) and (C), percentages of adipose tissue and fibrosis area in the gastrocnemius muscle. Data are mean ± SEM, n = 6, 3, 4, and 4 mice in C57BL/6 sham, C57BL/6 Isch, BALB/c sham, and BALB/c Isch group, respectively. *p < 0.05 vs. C57BL/6 sham or BALB/c sham, respectively; ^# p < 0.05 vs. C57BL/6 Isch.