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The MALAT1-miRNA-mRNA regulatory network in lung injury. MALAT1 acts as a miRNA sponge to reduce miRNA activity and abrogate miRNA inhibition on targeted mRNAs. Thereby, MALAT1 regulates cell proliferation, cell apoptosis, inflammation response, and airway remodeling through the miRNA-mRNA axis, which can eventually affect the progression of lung injury.
