TABLE 1.

Role of lncRNA MALAT1 in acute lung injury.

Models	Expression	Functions	Role	References
ALI	Up	MALAT1↓→miR-181a-5p↑→Fas↓→ cell apoptosis↓, inflammatory responses↓	Promoter	Liu et al. (2021)
ALI	Up	MALAT1↓→miR-194-5p↑→FOXP2↓→cell apoptosis↓	Promoter	Nan et al. (2020)
ALI	Up	MALAT1↓→miR-17-5p↑→FOXA1↓→cell proliferation↑, cell apoptosis↓	Promoter	Wei et al. (2019b)
ALI	Up	MALAT1↓→miR-149↑→MyD88↓→NF-κB↓→inflammatory responses↓	Promoter	Liang et al. (2019)
ALI	Up	MALAT1↓→miR-146a↑→inflammatory responses↓	Promoter	Dai et al. (2018a)
ALI	Down	BML-111→MALAT1↑→TLR4↓→NF-κB↓, p38 MAPK↓→cell apoptosis↓, inflammation↓	Suppressor	Li et al. (2018a)
ARDS	Up	MALAT1↓→miR-150-5p↑→ICAM-1↓→cell apoptosis↓, lung injury↓	Promoter	Yao et al. (2020)

Abbreviations: ALI, acute lung injury; ARDS, acute respiratory distress syndrome; FOXA1, forkhead box protein A1; FOXP2, forkhead box P2; ICAM-1, intercellular adhesion molecule-1.MALAT1, metastasis-associated lung adenocarcinoma transcript 1; MAPK, mitogen-activated protein kinase; miRNA, microRNA; MyD88, myeloid differentiation factor 88; NF‐κB, nuclear factor‐kappaB; TLR4, Toll-like receptor 4.