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. 2022 Sep 16;13:952938. doi: 10.3389/fphar.2022.952938

FIGURE 1.

FIGURE 1

Disruption of the intestinal barrier and the function of the microbiota in sepsis. (A) Under healthy conditions, the intestinal epithelium consists of a single layer of intestinal epithelial cells (IECs), which is an important protective physical barrier that maintains intestinal homeostasis. (B) During sepsis, excessive release of inflammatory factors and loss of tight junction of epithelial cells leads to bacterial translocation and exacerbates the progression of sepsis.