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. Author manuscript; available in PMC: 2023 Jun 1.
Published in final edited form as: Mater Today (Kidlington). 2022 Feb 23;56:79–95. doi: 10.1016/j.mattod.2022.01.025

Fig 1.

Fig 1.

Potential, necessity and strategy to target multicellular communications in the TME by GNP. (A) The intrinsic tumor therapeutic potential of GNP has been demonstrated in CC, CAF or EC single-cell models, as well as CC-CAF, CC-EC, or CAF-EC two-cell bidirectional crosstalk models. (B) The impact of the triangular crosstalk among CC, CAF, and EC on tumor progression, desmoplasia and angiogenesis is not clear, nor is the effect of GNP on the crosstalk. (C) This study investigated the triangular crosstalk using ovarian cancer models and evaluated GNP as a potential multi-target agent.