Figure 1. Algorithm and Distribution of Patient Groups Over Time.

A, Algorithm for estimating the probability of recurrence-free survival (RFS) at baseline (3 months after completion of total neoadjuvant therapy [TNT]) and for updating it at subsequent conditional time points (using the previously validated clinical calculator⁴). B, Distribution of the 302 patients at baseline (3 months), 6 months, and 12 months after completion of TNT. Over time, patients moved from the watch-and-wait cohort due to regrowth or by choice and were recategorized by pathologic stage. cCR indicates clinical complete response; KM, Kaplan-Meier; pCR, pathologic complete response (pathologic classification T0N0); pNR, pathologic incomplete response; stage I, pathologic classification T1 or T2 with N0; stage II, pathologic classification T3 or T4 with N0; and stage III, pathologic classification T1 to T4 with N1 or N2.