TABLE 3.
Comprehensive information about the pharmacological effects and mechanisms of sinomenine in glioma.
| Pharmacological effect | Object | Drug administration | Possible mechanisms | References |
|---|---|---|---|---|
| Inhibit cell viability | *U87 cells *SF767 cells | 0.0625, 0.125, 0.25, 0.5, and/or 1 mM, for 24, 48, or 72 h | Trigger autophagy via ROS-Akt-JNK signaling | Jiang et al. (2018) |
| *Promote G0/G1 arrest | *U87 cells *SF767 cells | 0.125, 0.25, or 0.5 mM, 24 h | *Suppress NF-κB activation and MMP-2/9 expression *reverse NF-κB-mediated epithelial-mesenchymal transition | Jiang et al. (2017) |
| *Inhibit migration and invasion | ||||
| *Reduce tumor volume/weight | mice | *75 or 150 mg/kg | Trigger autophagy | Jiang et al. (2017) |
| *Inhibit cell proliferation | *i.p. | |||
| *Induce cell cycle arrest | *Once daily, 14 days |