Table 5.
The largest 8 clusters of depression biomarkers references co-citation, identified by subject headings.
| Cluster ID | Size | Silhouette | Mean (cite Year) | Label (LSI) | Label (LLR) | Label (MI) |
|---|---|---|---|---|---|---|
| 0 | 245 | 0.787 | 2017 | Major depressive disorder | Inflammation | Adjunctive therapy |
| 1 | 191 | 0.862 | 2011 | Bipolar disorder | fMRI | Emotional processing bias |
| 2 | 166 | 0.901 | 2008 | c-reactive protein | Cytokines | Depression symptom dimensions |
| 3 | 143 | 0.876 | 2016 | Aging effect | Machine learning | Default mode network |
| 4 | 136 | 0.889 | 2007 | Brain-derived neurotrophic factor | Brain-derived neurotrophic factor | Nestin |
| 5 | 109 | 0.874 | 2012 | Gene expression | oxidative stress | Interleukin-1 receptor antagonist |
| 6 | 105 | 0.869 | 2016 | Risk prediction | Metabolomics | Cfs |
| 7 | 98 | 0.862 | 2012 | Cost effectiveness analysis | Microrna | Early nutrition |
LSI, Latent semantic indexing; LLR, log-likelihood ratio; MI, mutual information.