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. 2022 Apr 26;31(19):3245–3265. doi: 10.1093/hmg/ddac095

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© The Author(s) 2022. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Mutant (Ta3^fl/flNesCre) hippocampus is misshapen but with similar axonal organization. (A) Horizontal P15 sections of the hippocampus immuno-stained for neurofilament (165 kDa). The mutant (Ta3^fl/flNesCre) hippocampus is elliptical with a smaller dentate gyrus. The presubiculum (PrS) and parasubiculum (PaS) are reduced in size. Compass indicates orientation; C, caudal, L, lateral, M, medial, R, Rostral. (B) Sagittal P5 sections stained for neurofilament. Boxed areas indicate regions of higher magnification. (C) Axons of the performant pathway terminating in the ML and (D) radial axons of the CA1 field are similar between control and mutant. Scale bar: 250 μm (A), 100 μm (B), 25 μm.