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. 2022 Apr 26;31(19):3245–3265. doi: 10.1093/hmg/ddac095

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© The Author(s) 2022. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Talpid3 mutant SGZ has fewer radial glia cells and intermediate progenitors. BrdU was administered to P15 mice 2 h before euthanasia. (A) Immunohistochemical identification of BrdU incorporation in the dentate gyrus. BrdU positive cells were easily identifiable in the subgranular zone (SGZ) but few were visible in the GCL. (B) Quantitation of BrdU+ cells demonstrated that mutants (Ta3^fl/flNesCre) showed a significant reduction in the SGZ. (C) P10 mutant (Ta3^fl/flNesCre) and control (Ta3^fl/fl) dentate gyrus immuno-stained for PCNA and Tbr2. Mutant (Ta3^fl/flNesCre) exhibit loss of progenitors in the SGZ and ectopic progenitors in the SGZ (arrows). Scale bars: 100 μm (A), 75 μm (C). Error bars: (B) SEM (n = 3), ^***P ≤ 0.001, Student’s t-test.