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. 2022 Apr 26;31(19):3245–3265. doi: 10.1093/hmg/ddac095

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© The Author(s) 2022. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Talpid3 mutant glia scaffold is abnormal and insufficient for progenitor migration. (A–C) P5 dentate gyrus immuno-stained for GFAP and Sox2. Loss of GFAP fibres in the ML (ML) and radial fibres stretching through the GCL is seen in the mutant (Ta3^fl/flNesCre). Sox2+ progenitors are evenly distributed across the glial scaffold in the control (Ta3^fl/flNesCre). In the mutant (Ta3^fl/flNesCre) many progenitors are found clustered on a single fibre (Solid arrow). Box indicates region of higher magnification. Scale bars: 75 μm (A), 25 μm (B, C).