Table 1.
SIOOT protocol for the treatment of SARS-CoV-2 infection.
| covid-19 phenotype | Clinical features | Therapy protocol | Other |
|---|---|---|---|
| 1 | Fever, with/without respiratory symptoms, chest CT negative, normal saturimetry | No hospitalization. Home therapy with NSAIDs and ASA. 2–3 sessions of O2-O3-AHT(major, O2-O3-MAHT) per week for 2–3 weeks (40–50 μg/150–200 ml ozone in 150/200 ml blood). Sano3 bag |
Ozone oil Rinozone® nasal spray 2/day Ambient air sanitation (using AirKing®) |
| 2 | Fever-positive chest CT (few GGO) and/or low O2 Sat% | Hospitalization admission and follow-up 3 sessions O2-O3-MAHT per week for 3 weeks (40–50 μg/200 ml ozone in 200 ml blood). Sano3 bag | Ozone oil Rinozone® spray (ozonized oil) 2/3 times per day Hyper-ozonized water to drink (2 glasses/8 h) mouth and eye rinses Ambient air sanitation (using AirKing®) |
| 3 | Fever-positive chest CT (multiple GGO foci) and/or low O2 Sat% | Sub-intensive care needed O2 therapy (15 L/m) 4 sessions of O2-O3-MAHT per week for 3 weeks (40–50 μg/150–200 ml ozone in 150/200 ml blood). Rectal insufflation with ozone (20–30 μg/100 ml) | Ozone oil (Rinozone®) nasal spray 2–3/day Hyper-ozonized water to drink (2 glasses/8 h) mouth and eye rinses Ambient air sanitation (using AirKing®) |
| 4 | Pre-ARDS | Pre-ARDS CPAP 1st week: 1 session of O2-O3-MAHT/day for 7 days a week (40–50 μg/200 ml ozone in 200 ml blood) 2nd week: 4 sessions of O2-O3-MAHT /week (40–50 μg/200 ml ozone in 200 ml blood) 3rd week: 3 sessions of O2-O3-MAHT/week (40–50 μg/200 ml ozone in 200 ml blood). Rectal insufflation with ozone (20 μg/100 ml) | Ozone oil (Rinozone®) nasal spray 2–3/day Hyper-ozonized water to drink (2 glasses/8 h) mouth and eye rinses Ambient air sanitation (using AirKing®) |
| 5 | ARDS very low pO2 Sat% (up to 35–40 mmHg) Pulmonary Interstitial syndrome | CPAP attempt (in case of WET interstitial syndrome) Intubation (in case of DRY Interstitial syndrome) 1 session of O2-O3-MAHT /day for 5 days/week (40–50 μg/200 ml ozone in 200 ml blood). Rectal insufflation (20 μg/100 ml ozone) for 4 weeks | Ozone oil (Rinozone®) nasal spray 2–3/day Hyper-ozonized water to drink (2 glasses/8 h) mouth and eye rinses Ambient air sanitation (using AirKing® |
ARDS, Acute Respiratory Distress Syndrome; CPAP, continuous positive airway pressure; GGO, ground glass opacity, MAHT, major autohemotherapy.