Figure 10.

Solubilization attempts on various ion channels. (A) Depiction of KcsA and WSK-3. From left to right: KcsA with exposed residues to be mutated in the design, KcsA structure with side chains of mutated residues removed, and WSK-3. Reprinted with permission from ref (226). Copyright 2004 National Academy of Sciences. (B) NMR structure of WSK-3 (green) superimposed with KcsA crystal structure (PDB ID: 1K4C). Mutations made to facilitate solubility and AgTx₂ binding are highlighted in orange and black, respectively. Reprinted with permission from ref (234). Copyright 2008 National Academy of Sciences. (C) Ribbon diagram of MscL residues chosen for replacement to cysteine for polyethylene glycol-polyamide oligomer modifications. Reprinted with permission from ref (237). Copyright 2004 Elsevier.