Table 3.
Pathomorphological presentation of the study cohort.
| Variable, parameter | Unit or category | Total | Surgical remission | Response to first-generation SRLs | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Yes | No | p | Good | Poor | p | ||||||||
| N | Results | N | Results | N | Results | N | Results | N | Results | ||||
| Granulation subtype of tumor, n (%) | Densely | 108 | 59 (54.6) | 41 | 30 (73.2) | 60 | 24 (40.0) | 0.001 | 25 | 16 (64.0) | 27 | 4 (14.8) | <0.001 |
| Sparsely | 49 (45.4) | 11 (26.9) | 36 (60.0) | 9 (36.0) | 23 (85.2) | ||||||||
| Immunohistochemical evaluation of tumor, n (%) | Pure GH(+) | 118 | 63 (53.4) | 48 | 23 (47.9) | 63 | 34 (54.0) | 0.847 | 27 | 15 (55.6) | 29 | 17 (58.6) | 0.927 |
| GH(+) PRL(+) | 46 (39.0) | 21 (43.8) | 24 (38.1) | 10 (37.0) | 9 (31.0) | ||||||||
| Plurihormonal | 9 (7.6) | 4 (8.3) | 5 (7.9) | 2 (7.4) | 3 (10.3) | ||||||||
| Alpha-subunit, n (%) | (+) | 117 | 55 (47.0) | 48 | 28 (58.3) | 62 | 22 (35.5) | 0.021 | 27 | 11 (40.7) | 29 | 8 (27.6) | 0.299 |
| Ki-67 Index, n (%) | Ki-67 < 1 | 116 | 89 (76.7) | 48 | 42 (87.5) | 61 | 40 (65.6) | 0.002 | 26 | 18 (69.2) | 29 | 16 (55.2) | 0.094 |
| 1 ≤ Ki-67 < 3 | 16 (13.8) | 6 (12.5) | 10 (16.4) | 6 (23.1) | 4 (13.8) | ||||||||
| Ki-67 ≥ 3 | 11 (9.5) | 0 (0.00) | 11 (18.0) | 2 (7.7) | 9 (31.0) | ||||||||
The bold values are statistically significant.