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. 2022 Sep 16;9:1016071. doi: 10.3389/fmolb.2022.1016071

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14-3-3 binding motifs. (A) The canonical mode I phosphopeptide (sequence ARSH(pS)YPA) bound to 14-3-3ζ (PDB ID: 1QJB) (Rittinger et al., 1999). (B) The canonical mode II phosphopeptide (sequence RLYH(pS)LPA) bound to 14-3-3ζ (PDB ID: 1QJA) (Rittinger et al., 1999). (C) The canonical mode III phosphopeptide derived from the C-terminus of human DAPK2 (sequence RRSS(pT)S) bound to 14-3-3γ (PDB ID: 7A6R) (Horvath et al., 2021). (D) The non-phosphorylated ExoS peptide (sequence GHGQGLLDALDLAS) bound to 14-3-3ζ (PDB ID: 2O02) (Ottmann et al., 2007b). (E) The non-phosphorylated R18 peptide derived from phage display (sequence WLDLE) bound to 14-3-3ζ (PDB ID: 1A38) (Petosa et al., 1998). (F) The glycosylated Ser-O-GlcNAc peptide (sequence ATPPV(S-O-GlcNAc)QASSTTT) bound to 14-3-3γ (PDB ID: 6BYJ) (Toleman et al., 2018). The figure was prepared with PyMOL (https://pymol.org/2/).