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APL-9 lowers complement activation in NAb-positive and negative blood. C3a levels in whole blood measured 90 minutes post AAV-Spark100 (5×1011 vg/mL) addition with or without APL-9. Bars represent the mean fold change ± SEM relative to unstimulated cells. Symbols represent the individual values in samples. Significance was determined with a two-way RM-ANOVA with Sidak’s multiple comparison test. *p ≤ 0.05; ***p ≤ 0.001; ****p ≤ 0.0001. ns, not significant.
