Skip to main content
. 2022 Sep 16;12:1004608. doi: 10.3389/fcimb.2022.1004608

Figure 1.

Figure 1

DENV evasion of innate immune responses. DENV non-structural proteins such as NS2a, NS2b, NS3, NS4a and NS4b are known to modulate innate immunity by counteracting the type I IFN-mediated antiviral response. TLR3, Toll-like receptor 3; TLR7, Toll-like receptor 7; NS2a, Non-structural 2a protein; NS2b, Non-structural 2b protein; NS3, Non-structural 3 protein; NS4a, Non-structural 4a protein; NS4b, Non-structural 4b protein; IRF3, Interferon regulatory factor 7; IRF7, Interferon regulatory factor 7; cGAS, Cyclic GMP-AMP synthase; cGAMP, Cyclic GMP-AMP; IKKα, IκB kinase-alpha; IKKβ, IκB kinase-beta; IKKƔ, IκB kinase-gamma; TRAF6, Tumor necrosis factor receptor-associated factor 6; MAVS, Mitochondrial antiviral signaling; MyD88, Myeloid differentiation primary response gene 88; TBK1/IKKϵ, TANK-binding kinase 1/IκB kinase-epsilon; RIG-1, Retinoic acid-inducible gene 1; MDA5, Melanoma differentiation-associated protein 5; TRIF, TIR-domain-containing adapter inducing IFN-β.