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. 2022 Sep 29;23(1):125. doi: 10.1186/s10194-022-01495-9

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Spiking neuron network embedding the FHM1 synaptic alterations. A (left) Schematic representation of the synaptic alterations experimentally observed in [15, 16] (left) and implemented in our computational model (right). B Mean PSD of experimental and simulated LFPs for WT (left) and FHM1 (right) mice during pre-stimulus baseline. The shaded regions indicate the standard deviation of experimental PSDs. C Simulated normalized MUA of WT (orange) and FHM1 (green) model. D Inhibitory over excitatory ratio in the simulated WT (orange) and FHM1 (green) computational model across simulated K. 2WRMA, K: F > 1000; group: F > 1000; interaction: F = 646.2. E (top and middle) PSD modulation for the maximum contrast level (K = 90) of experimental (black) and simulated data for WT (orange, top) and FHM1 (green, middle). See also Fig. S1 A-B for responses to low contrasts. (bottom) Mean difference between the simulated WT and FHM1 spectral modulations (shaded error bar indicate standard deviation of bootstrapped mean difference)