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. 2022 Sep 29;23(1):125. doi: 10.1186/s10194-022-01495-9

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Cortico-cortical and thalamocortical gain-of-function and thalamocortical asymmetry differentially contributed to shaping cortical dynamics in FHM1 computational model. A Schematics of the FHM1 computational model when considering only the thalamocortical (TC) synaptic increase (represented by sand-colored arrows with thickness proportional to synaptic strength). B Modulation of excitatory (dashed black line) and inhibitory (black line) firing rate across TC synaptic increase levels (mean ± std). The modulation was computed with respect to the simulated pre-stimulation baseline firing rate. 2WRMA TC: F = 474.85; neuronal type: F = 25,579; interaction: F = 3291.9. See also Fig. S1 C. C Inhibitory over excitatory ratio (averaged across contrast levels) in the simulated excitatory neurons across TC increase levels (mean ± std). 2WRMA TC: F > 1000; K: F > 1000; interaction: F = 49.30. See also Figs. S1 F, I, S3 E. D PSD modulations of the simulated LFPs at K = 90 with respect to pre-stimulation across TC increase levels. E Ratio of high over low broad ɣ band of PSD modulation of simulated LFPs across TC increase levels. See also Fig. S3 B-D, F. F-L Same as (A-E) but across IC increase levels. G 2WRMA IC: F = 293.93; neuronal type: F > 1000; interaction: F = 614.09. See also Fig. S1 D. H 2WRMA K: F > 1000; IC: F = 585.83; interaction: F = 44.53. See also Fig. S1 G,L, S3 M. L See also Fig. S3 H-L, N. M-Q Same as (A-E) but across TCA levels. N 2WRMA TCA: F = 649.57; neuronal type: F > 1000; interaction: F = 251.39. See also Fig. S1 E. O 2WRMA TCA: F > 1000; K: F > 1000; interaction: F > 1000. See also Figs. S1 H, M, S3 S. Q See also Fig. S3 P-R, T