Table 2.
Relative odds of diabetes according to uACR in different models among US adults
| uACR, mg/g† | Events (%) | Diabetes OR (95% CI), P value | ||
|---|---|---|---|---|
| Model 1 | Model 2 | Model 3 | ||
| All participants | ||||
| Continuous (Lg uACR) | 818 (15.41%) | 3.89 (3.36, 4.50), < 0.001 | 1.90 (1.47, 2.46), < 0.001 | 1.81 (1.39, 2.34), < 0.001 |
| Tertile 1 (< 5) | 119 (6.73%) | Reference | Reference | Reference |
| Tertile 2 (5–10) | 221 (12.49%) | 1.98 (1.57, 2.50), < 0.001 | 1.36 (0.97, 1.91), 0.079 | 1.37 (0.97, 1.94) 0.077 |
| Tertile 3 (≥ 10) | 478 (27.02%) | 5.13 (4.15, 6.36), < 0.001 | 1.86 (1.33, 2.59), < 0.001 | 1.82 (1.29, 2.56), < 0.001 |
| P for trend | < 0.001 | < 0.001 | < 0.001 | |
| Male | ||||
| Continuous (Lg uACR) | 484 (17.06%) | 4.75 (3.91, 5.76), < 0.001 | 2.43 (1.72, 3.42), < 0.001 | 2.26 (1.59, 3.21), < 0.001 |
| Tertile 1 (< 4) | 62 (6.55%) | Reference | Reference | Reference |
| Tertile 2 (4–8) | 116 (12.28%) | 2.00 (1.45, 2.75), < 0.001 | 1.10 (0.68, 1.79), 0.693 | 1.11 (0.67, 1.81) 0.691 |
| Tertile 3 (≥ 8) | 306 (32.35%) | 6.82 (5.09, 9.12), < 0.001 | 1.95 (1.22, 3.10), 0.005 | 1.94 (1.20, 3.13) 0.007 |
| P for trend | < 0.001 | 0.002 | 0.003 | |
| Female | ||||
| Continuous (Lg uACR) | 334 (13.52%) | 2.99 (2.36, 3.78), < 0.001 | 1.23 (0.79, 1.90), 0.359 | 1.28 (0.82, 2.01), 0.278 |
| Tertile 1 (< 6) | 66 (8.02%) | Reference | Reference | Reference |
| Tertile 2 (6–11) | 93 (11.30%) | 1.46 (1.05, 2.04), 0.025 | 0.95 (0.59, 1.53), 0.843 | 0.96 (0.59, 1.57), 0.881 |
| Tertile 3 (≥ 11) | 175 (21.24%) | 3.09 (2.29, 4.18), < 0.001 | 1.07 (0.67, 1.70), 0.784 | 1.11 (0.68, 1.80), 0.678 |
| P for trend | < 0.001 | 0.751 | 0.644 | |
| P value for interaction* | 0.003 | 0.014 | 0.049 | |
Values are ORs (95% CIs) unless otherwise indicated. uACR, albumin-to-creatinine ratio. †uACR value was log10-transformed
Model 1 was adjusted for none
Model 2 was adjusted for age, sex (only for overall population), race, poverty income ratio, BMI, SBP, DBP, current smoking, alcohol intake, FPG, TG, TC, HDL, LDL
Model 3 was adjusted for age, sex (only for overall population), race, poverty income ratio, BMI, SBP, DBP, hypertension, current smoking, alcohol intake, FPG, TG, TC, HDL, LDL, eGFR, antihypertensive drugs, lipoprotein-lowering drugs
*P value for interaction test: two-way interaction of sex and LguACR (continuous) on diabetes