Fig. 3.

Anti-LAG3 synergizes with MWA to inhibit tumor outgrowth A. Schematic drawing for the therapeutic treatment in our present study. A total of 3 × 10⁶ MC38 cells were subcutaneously inoculated into the bilateral flanks (1.5 × 10⁶ MC38 cells for each side) of C57BL/6 mice. Mice bearing the MC38 tumor were divided into four groups. B. The tumor size on the left flank was measured three times every week after MWA, showing that the LAG3 blockade plus MWA significantly decreased the tumor growth (n = 5 for each group). C. Log-rank survival analysis shows LAG3 blockade plus MWA treatment significantly prolonged the OS of the tumor-bearing mice (n = 10 for the control group, and for the other three groups, n = 7 respectively). ^*P < 0.05, ^**P < 0.01, ^***P < 0.001