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. 2022 Sep 30;20:433. doi: 10.1186/s12967-022-03646-7

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 8 — Combined therapy of MWA and LAG3 blockade alters the cell–cell communication across all immune subsets. A. The cell–cell communication among immune cell populations between the MWA group and MWA in combination with LAG3 blockade group. B. Bar plot showing the relative information flow between the MWA group and MWA combined with the LAG3 blockade group. C. Chord plot showing the specific cell–cell interaction with the CXCL signaling pathway. D. Dot plot showing the genes of the CXCL signaling pathway among different clusters. E. Dot plot showing the genes of IFNG signaling pathway among different clusters