Table 1.
Patients’-characteristics gynaecological malignancies.
| Endometrial Cancer (EC) | Ovarian Cancer (OC) | ||||||||
| Parameter n (%) (+/- SD) | total n=152 | transfused n=19 | non- transfused n=133 | total n=111 | transfused n=57 | non- transfused n=54 | |||
| Mean age [years] | 71.0 (+/- 7.4) | 70.9 (+/- 5.9) | |||||||
| Clinical-pathological cancer characteristics | |||||||||
| Tumor Stage (FIGO-Stage) | p<0.001 | p=0.483 | |||||||
| I | 123 (80.9) | 11 (57.9) | 111 (84.1) | 13 (11.2) | 4 (7.0) | 9 (16.7) | |||
| Ia | 70 (46.1) | Ia | 8 (6.9) | ||||||
| Ib | 53 (34.9) | Ib | 1 (0.9) | ||||||
| Ic* | 4 (3.4) | ||||||||
| II | 7 (4.6) | 0 (0.0) | 7 (5.3) | 6 (5.2) | 3 (5.3) | 3 (5.6) | |||
| IIa | 2 (1.7) | ||||||||
| IIb | 4 (3.4) | ||||||||
| III | 12 (7.9) | 2 (10.5) | 10 (7.6) | 74 (63.8) | 36 (63.2) | 35 (64.8) | |||
| IIIa | 2 (1.3) | IIIa1 | 5 (4.3) | ||||||
| IIIb | 3 (2.0) | IIIa2 | 0 (0.0) | ||||||
| IIIc1 | 5 (3.3) | IIIb | 13 (11.2) | ||||||
| IIIc2 | 2 (1.3) | IIIc | 56 (48.3) | ||||||
| IV | 10 (6.6) | 6 (31.6) | 4 (3.0) | 17 (14.7) | 10 (17.5) | 7 (13.0) | |||
| IVa | 3 (2.0) | 2 (1.7) | |||||||
| IVb | 7 (4.6) | 15 (12.9) | |||||||
| Histological Subtype | p=0.005 | p=0.824 | |||||||
| Endo-metrioid | 130 (85.0) | 12 (63.2) | 117 (88.0) | Serous | 86 (74.1) | 18 (31.6) | 16 (29.6) | ||
| low grade | 5 (4.3) | ||||||||
| high grade | 81 (69.8) | ||||||||
| Others | 23 (15.0) | 7 (36.8) | 16 (12.0) | Others | 30 (25.9) | 39 (68.4) | 38 (70.4) | ||
| (serous, squamous, mucinous,) | (endometrioid, mucinous, clear cell) | ||||||||
| Histological grade of differentiation | p=0.774 | p=0.560 | |||||||
| G1 | 75 (49.0) | 7 (36.8) | 67 (50.4) | 6 (5.2) | 2 (3.5) | 4 (7.4) | |||
| G2 | 46 (30.1) | 6 (31.6) | 40 (30.1) | 21 (18.1) | 9 (15.8) | 11 (20.4) | |||
| G3 | 30 (19.6) | 4 (21.1) | 26 (19.5) | 87 (75.0) | 44 (77.2) | 39 (72.2) | |||
| Red blood cell transfusion management | |||||||||
| Timing of transfusion | |||||||||
| preoperative intraoperative postoperative |
4 (21.1) 12 (63.2) 3 (15.8) |
6 (10.5) 42 (73.7) 9 (15.8) |
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| Number of transfusions | |||||||||
| ≤ 5> 5 | 16 (84.2)3 (15.8) | 38 (66.7)19 (33.3) | |||||||
| Preoperative anemia of cancer | |||||||||
| [g/dl] | p<0.001 | p=0.030 | |||||||
| Haemoglobin < 12 | 35 (23.3) | 14 (77.8) | 21 (15.9) | 40 (37.4) | 26 (47.3) | 14 (26.9) | |||
| Haemoglobin > 12 | 115 (76.7) | 4 (22.2) | 111 (84.1) | 67 (62.6) | 29 (52.7) | 38 (73.1) | |||
| Global health status | |||||||||
| G8 Score | p<0.001 | p=0.031 | |||||||
| G8-frail G8-non-frail |
58 (38.9) 91 (61.1) |
15 (83.3) 3 (16.7) |
43 (33.1) 87 (66.9) |
51 (48.1) 55 (51.9) |
32 (58.2) 23 (41.8) |
19 (37.3) 32 (62.7) |
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| Surgical treatment parameters | |||||||||
| Postoperative Residual tumor burden |
p=0.150 | p=0.017 | |||||||
| None Present Unknown |
144 (94.7) 6 (3.9) 2 (1.3) |
16 (84.2) 2 (10.5) 1 (5.3) |
127 (95.5) 4 (3.0) 2 (1.5) |
67 (58.3) 48 (41.7) 0 (0.0) |
27 (47.4) 30 (52.6) 0 (0.0) |
37 (68.5) 16 (29.6) 0 (0.0) |
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| SCS – Surgical Complexity Score | n.a. | p=0.062 | |||||||
| SCS 1 SCS 2 SCS 3 |
37 (33.3) 53 (47.7) 21 (18.0) |
16 (28.1) 26 (45.6) 15 (26.3) |
21 (39.6) 27 (50.9) 5 (9.4) |
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| Completeness of systemic therapy | p=0.425 | p=0.841 | |||||||
| No Yes |
2 (14.3) 12 (85.7) |
0 (0.0) 3 (25.0) |
2 (100.0) 9 (75.0) |
13 (16.0) 68 (84.0) |
6 (16.2) 31 (83.8) |
7 (17.9) 32 (82.1) |
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EC, endometrial cancer; FIGO, International Federation of Gynecology and Obstetrics; G, histological grade of differentiation; G8 Score, G8 geriatric Screening tool; G8 frail, G8 geriatric Screening tool > 14 points; G8 non-frail, G8 geriatric Screening tool ≤ 14 points; OC, ovarian cancer; SD, standard deviation; SCS, Surgical Complexity Score.
n.a.: not applicable, n: number of patients.
*if the number of cases is small, the subdivision into IC1, IC2 and IC3 is waived.
bold written words: analyzed main categories.
bold written numbers: statistically significant results (p<0.05); italic written numbers: clinically relevant results (p<0.1).