Table 3.
Uni- and multivariable Cox-regression analyses for survival in patients with gynecological malignancies.
| Endometrial Cancer | Ovarian Cancer | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| univariable | PFS | OS | PFS | OS | ||||||||
| HR | 95%- CI | p-value | HR | 95%- CI | p-value | HR | 95%- CI | p-value | HR | 95%- CI | p-value | |
| TNM-Tumor Stage | 1.48 | 0.89-2.47 | 0.134 | 2.21 | 1.56-3.15 | <0.001 | 2.56 | 1.48-4.42 | 0.001 | 3.41 | 1.86-6.22 | <0.001 |
| FIGO-Stage | 1.87 | 1.34-2.61 | <0.001 | 2.25 | 1.69-2.99 | <0.001 | 6.21 | 1.91-20.18 | 0.002 | 1.96 | 1.32-2.89 | 0.001 |
| Histological subtype | 0.45 | 0.18-1.12 | 0.087 | 0.34 | 0.16-0.73 | 0.006 | 1.52 | 0.80-2.86 | 0.200 | 1.77 | 0.93-3.36 | 0.083 |
| Histological grade of differentiation | 1.93 | 1.19-3.12 | 0.008 | 2.26 | 1.44-3.55 | <0.001 | 1.59 | 0.91-2.80 | 0.104 | 1.71 | 0.98-2.97 | 0.057 |
| Postoperative residual tumor burden | 2.22 | 1.06-4.65 | 0.034 | 2.95 | 1.71-5.08 | <0.001 | 2.07 | 1.17-3.67 | 0.012 | 3.03 | 1.70-5.41 | <0.001 |
| SCS – Surgical Complexity Score | - | 1.46 | 0.96-2.22 | 0.078 | 1.509 | 1.01-2.26 | 0.045 | |||||
| Completeness of systemic therapy | - | 2.06 | 0.87-4.85 | 0.071 | 0.984 | 0.49-1.96 | 0.963 | |||||
| RBC transfusions | 4.97 | 2.03-12.18 | <0.001 | 7.48 | 3.48-16.08 | <0.001 | 1.10 | 0.62-1.98 | 0.743 | 1.66 | 0.95-2.93 | 0.078 |
| Preoperative anemia of cancer (AOC) | 0.53 | 0.24-1.18 | 0.118 | 0.29 | 0.15-0.58 | 0.001 | 0.58 | 0.31-1.10 | 0.097 | 0.46 | 0.26-0.83 | 0.010 |
| G8 geriatric Screening tool (G8 Score) | 2.29 | 1.04-5.02 | 0.040 | 3.55 | 1.73-7.26 | 0.001 | 2.14 | 1.17-3.92 | 0.014 | 1.49 | 0.86-2.57 | 0.154 |
| multivariable | ||||||||||||
| TNM-Tumor Stage | – | 0.92 | 0.54-1.56 | 0.759 | 1.25 | 0.45-3.47 | 0.671 | 3.75 | 1.87-7.53 | <0.001 | ||
| FIGO-Stage | 1.25 | 1.06-1.46 | 0.007 | 1.30 | 1.13-1.49 | <0.001 | 6.52 | 1.51-28.07 | 0.012 | 1.10 | 0.12-9.89 | 0.932 |
| Histological Subtype | 3.17 | 0.82-12.33 | 0.096 | 3.83 | 1.15-12.74 | 0.029 | - | 1.38 | 0.70-2.73 | 0.351 | ||
| Histological grade of differentiation | 2.25 | 1.22-4.14 | 0.009 | 2.11 | 1.23-3.61 | 0.007 | - | 1.45 | 0.72-2.93 | 0.299 | ||
| Postoperative residual tumor burden | 1.29 | 0.51-3.25 | 0.586 | 1.29 | 0.57-2.91 | 0.543 | 1.35 | 0.70-2.63 | 0.375 | 0.83 | 0.42-1.67 | 0.605 |
| SCS | – | 1.08 | 0.65-1.79 | 0.778 | 1.03 | 0.64-1.65 | 0.899 | |||||
| Completeness of systemic therapy | – | 1.81 | 0.68-4.80 | 0.231 | - | |||||||
| RBC transfusions | 1.76 | 1.01-3.07 | 0.046 | 2.38 | 1.50-3.78 | <0.001 | - | 0.85 | 0.43-1.68 | 0.643 | ||
| Preoperative AOC | – | 1.07 | 0.50-2.30 | 0.860 | 1.18 | 0.59-2.38 | 0.644 | 1.70 | 0.92-3.15 | 0.090 | ||
| G8 Score | 1.34 | 0.53-3.36 | 0.533 | 2.02 | 0.87-4.67 | 0.101 | 2.23 | 1.16-4.32 | 0.017 | - | ||
95%-CI, confidence interval; FIGO, International Federation of Gynecology and Obstetrics; G8 Score, G8 geriatric Screening tool; HR, hazard ratio; OS, overall survival; PFS, progression free Survival; RBC, red blood cell; SCS, Surgical Complexity Score.
n = number of patients.
bold written words: analyzed main categories;.
bold written numbers: statistically significant results (p<0.05); italic written numbers: clinically relevant results (p<0.1).