Table 2.

Change in self-report questionnaires (estimated means).

		Placebo (n = 41)						Ocimum tenuiflorum (n = 44)						p -valueb
		Week 0	Week 2	Week 4	Week 6	Week 8	p-valuea	Week 0	Week 2	Week 4	Week 6	Week 8	p -valuea
PSS	Mean	22.08	18.48	18.36	16.97	17.80	0.004	21.74	17.28	16.09	14.00	13.72	0.001	0.003
	SE	6.47	5.44	5.47	5.19	5.30		6.38	5.09	4.75	4.08	3.97
AIS	Mean	12.15	8.36	8.80	8.52	8.91	0.028	11.29	8.10	7.57	6.58	5.87	0.010	0.025
	SE	4.51	3.12	3.30	3.21	3.37		4.20	3.03	2.84	2.48	2.21
RSQ	Mean	37.51	48.59	52.07	51.79	57.00	0.003	37.96	48.11	52.72	54.43	58.15	0.002	0.984
	SE	10.91	14.11	15.11	15.10	16.58		11.05	13.97	15.29	15.84	16.88
POMS-Total mood disturbance	Mean	117.61	113.87	109.36	107.06	97.30	<0.001	111.86	104.46	99.82	96.26	94.53	<0.001	0.695
	SE	17.20	16.70	16.13	15.85	14.28		16.36	15.32	14.71	14.22	13.83
PROMIS-physical function	Mean	5.00		5.42		4.98	0.970	4.68		4.76		4.55	0.668	0.800
	SE	0.98		1.08		1.00		0.92		0.95		0.91
PROMIS-Anxiety	Mean	9.27		8.31		7.38	0.022	8.64		6.96		5.54	0.002	0.131
	SE	2.59		2.35		2.08		2.42		1.7		1.56
PROMIS-Depression	Mean	7.58		7.35		6.06	0.057	6.72		6.40		6.04	0.274	0.576
	SE	2.24		2.18		1.81		1.99		1.89		1.76
PROMIS-Fatigue	Mean	13.16		10.72		10.12	0.003	12.98		10.20		9.41	0.001	0.796
	SE	3.08		2.53		2.40		3.04		2.40		2.22
PROMIS-Sleep disturbance	Mean	14.80		11.52		11.86	0.001	14.62		11.10		10.21	<0.001	0.133
	SE	3.16		2.49		2.56		3.13		2.40		2.20
PROMIS-Social	Mean	10.20		7.94		7.74	0.017	10.50		8.19		7.33	0.007	0.743
	SE	3.10		2.45		2.39		3.19		2.52		2.26

Results (estimated means) are generated from generalized mixed-effects models adjusted for age, sex, and BMI.

^aP-values are generated from repeated measures generalized mixed-effects models adjusted for age, sex, and BMI (time effects baseline and week 8).

^bP-values are generated from repeated measures generalized mixed-effects models adjusted for age, sex, and BMI (time x group interaction).