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In vitro metabolic stability study of cjoc42, as well as compounds 51b, 51c, 51d, 52b and 52d.
| Compound | % Metabolic stabilitya |
|---|---|
|
| |
| cjoc42 | 50 ± 5.1 |
| 51b | 84 ± 9.0 |
| 51c | 87 ± 3.3 |
| 51d | 60 ± 11.0 |
| 52b | 73 ± 0.8 |
| 52d | 80 ± 3.5 |
Metabolic stability was calculated as the % compound remaining after 60 min of incubation with human liver microsomes.
