Figure 1.

Time course and pattern of wound angiogenesis. Over time, capillaries grow in the wound bed, reaching a density that is 3–10 times that of normal tissue. During the resolution phase, most of these vessels are removed. Studies in multiple systems, including mouse, human, and pig, have identified the major proangiogenic factors (green) and regression/maturation signals (red) in excisional wounds. Dashed line (blue) represents vascular density in normal unwounded tissue (Nissen et al. 1996, 1998; Artuc et al. 1999; Swift et al. 1999; Wietecha et al. 2011, 2015).