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. 2022 Sep 30;12:16419. doi: 10.1038/s41598-022-20818-z

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Reports means and 95% confidence intervals. (A) Reports mean dialysate concentrations of inflammatory mediators at T1 (baseline) and T3 (after switching treatments) in the intention to treat population. Comparison of treatments: MCO versus high flux dialysis was done using unpaired ANOVA on n = 42 MCO treated versus 39 high flux treated patients × sample pairs, comparable results were obtained on the per protocol population using linear mixed models (not shown). (B) Mean YKL-40 serum levels were assayed at all 4 study timepoints in the ITT population after the dialysis session (4 h—sample). (C) Mean YKL-40 serum levels were assayed at all 4 study timepoints in the ITT population before the dialysis session (0 h—sample) (B, C) The thin connecting horizontal lines between timepoints (T1–T4) represent repeated measures from subject IDs within sequence 1 (MCO → wash out → high flux). A linear mixed effects model was built with subject ID, nested in sequence, as a random effect and treatment (MCO = 1), period and sequence as the main effects. A P value for treatment < 0.05 in the absence of carry over effect was considered statistically significant.