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. 2022 Sep 30;611(7934):115–123. doi: 10.1038/s41586-022-05165-3

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© The Author(s) 2022, corrected publication 2022

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Fig. 3 — Overlap enrichment analysis using GREP²² (top). Middle, integrating MR results using cis- and trans-pQTLs as instrumental variables with data from drug databases. Bottom, negative correlation tests between compound-regulated gene expression profiles and genetically determined case–control gene expression profiles using Trans-Phar.