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. Author manuscript; available in PMC: 2022 Sep 30.
Published in final edited form as: ACS Catal. 2021 May 26;11(12):6787–6799. doi: 10.1021/acscatal.1c00745

Figure 3: Crosslinking probes.

Figure 3:

Comparison of acyl-AcpP with crosslinker-loaded crypto-AcpPs utilized in this study to trap and crystalize AcpP=FabF complexes. An acyl-ACP substrate is shown to demonstrate the chemical structure of the natural substrate. The two crosslinking pantetheinamide probes have an amide instead of a thioester linking their acyl substrates as well as either an α-bromo or chloroacrylamide warhead. The region that has been modified to facilitate stable crosslinkers is shown in red while the substrate mimetics are outlined in light green. (ONE COLUMN)