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. Author manuscript; available in PMC: 2022 Sep 30.
Published in final edited form as: ACS Catal. 2021 May 26;11(12):6787–6799. doi: 10.1021/acscatal.1c00745

Figure 4: C16:1- and C8-AcpP=FabF active site organization.

Figure 4:

A) 2D schematic of C16:1-AcpP=FabF active site. The oxyanion hole is not formed and Phe400 is rotated away from the active site. B) 3D rendering of C16:1-AcpP=FabF active site and crosslinker. C) Acyl-binding pocket of C16:1-AcpP=FabF compared to that of C12-FabF (PDB: 2GFY). D) 2D schematic of C8-AcpP=FabF active site. The oxyanion hole is formed and the gating loops are in the closed conformation. E) 3D rendering of C8-AcpP=FabF active site and crosslinker. F) Acyl-binding pocket of C8-AcpP=FabF compared to C12-FabF (PDB: 2GFY). In panels C and F structural alignments were performed over all atoms. (TWO COLUMN)_