Table 1.
Clinical and Infectious Characteristics
| Neurologic Dysfunction Absent (n=480) | Neurologic Dysfunction Present | P value a,b (All groups) | P value b,c (Comparison between patients with Neurologic Dysfunction only) | ||
|---|---|---|---|---|---|
| At Sepsis Recognition (n=61) | After Sepsis Recognition (n=26) | ||||
| Age, years (median [IQR]) | 3 [0.7-10] | 7 [0.9-12] | 4 [0.5-14] | 0.18 | 0.47 |
| Male (n, %) | 257 (54) | 29 (48) | 16 (62) | 0.49 | 0.25 |
| Comorbid Conditions (n, %) | |||||
| Respiratory | 150 (31) | 12 (20) | 10 (36) | 0.11 | 0.10 |
| Gastrointestinal | 124 (26) | 10 (16) | 7 (27) | 0.27 | 0.38 |
| Cardiovascular | 121 (25) | 10 (16) | 5 (19) | 0.28 | 0.76 |
| Genetic | 103 (22) | 8 (13) | 4 (15) | 0.28 | 0.75 |
| Hematologic/Immunologic | 100 (21) | 9 (15) | 5 (19) | 0.56 | 0.75 |
| Neuromuscular | 80 (17) | 12 (20) | 5 (19) | 0.76 | 1.00 |
| Neoplastic | 70 (15) | 8 (13) | 2 (8) | 0.72 | 0.72 |
| Prematurity | 73 (15) | 2 (3) | 1 (4) | 0.008 | 1.00 |
| Metabolic | 52 (11) | 8 (13) | 2 (8) | 0.80 | 0.72 |
| Renal | 45 (9) | 7 (12) | 3 (12) | 0.72 | 1.00 |
| Solid organ/Stem cell transplant | 47 (10) | 4 (7) | 3 (12) | 0.67 | 0.42 |
| Number of comorbidities (n, %) | 0.09 | 0.61 | |||
| None | 100 (21) | 21 (34) | 7 (27) | ||
| 1 | 118 (25) | 17 (28) | 6 (23) | ||
| 2 or more | 262 (55) | 23 (38) | 13 (50) | ||
| Admission Type (n, %) | <0.001 | 0.09 | |||
| Medical | 389 (81) | 47 (77) | 24 (92) | ||
| Surgical | 80 (17) | 5 (8) | 2 (8) | ||
| Trauma | 11 (2) | 9 (15) | 0 (0) | ||
| Non-Neurologic PIM3 Risk of Mortality (%, median [IQR]) | 3.7 [1.6-7.2] | 8.7 [3.9-20.2] | 6.2 [4.3-11.1] | <0.001 | 0.09 |
| Non-Neurologic Organ Dysfunction, Day 1 (n, %) | 0.002 | 0.11 | |||
| None | 92 (19) | 3 (5) | 5 (19) | ||
| 1 | 151 (32) | 20 (33) | 10 (39) | ||
| 2 | 185 (39) | 23 (38) | 5 (19) | ||
| More than 3 | 52 (11) | 15 (25) | 6 (23) | ||
| Primary Site of Infection (n, %) | <0.001 | 0.11 | |||
| Respiratory | 199 (41) | 21 (34) | 8 (31) | ||
| Bloodstream | 89 (19) | 9 (15) | 10 (38) | ||
| Central Nervous System | 14 (3) | 10 (17) | 2 (8) | ||
| Other | 178 (37) | 21 (34) | 6 (23) | ||
| Bacterial Isolate (n, %) | 231 (48) | 35 (57) | 13 (50) | 0.38 | 0.64 |
| Viral Isolate (n, %) | 93 (19) | 16 (26) | 8 (31) | 0.17 | 0.79 |
| Fungal Isolate (n, %) | 60 (13) | 5 (8) | 6 (23) | 0.17 | 0.08 |
IQR = interquartile range, PIM = Pediatric Index of Mortality;
a
= Fisher’s exact test or Kruskal-Wallis test across groups;
b
= multiple comparisons p-value threshold for significance <0.0024;
c
= Fisher’s exact test or Mann-Whitney U test between groups