Table 3.
Multivariable Analysis Showing Association Between Neurologic Dysfunction and Confounders to Primary Outcome (Mortality or New Moderate Disability at Hospital Discharge)
| Variable | aOR | 95% CI | P value |
|---|---|---|---|
| Neurologic Dysfunction | |||
| None | Reference | ||
| At Sepsis Recognition | 4.9 | 2.3-10.1 | <0.001 |
| After Sepsis Recognition | 10.7 | 3.8-30.5 | <0.001 |
| POPC score, baseline | |||
| 1 | Reference | ||
| 2 | 1.3 | 0.8-2.4 | 0.32 |
| 3 | 0.8 | 0.4-1.4 | 0.39 |
| 4 | 0.2 | 0.1-0.4 | <0.001 |
| 5 | 0.3 | 0.0-4.5 | 0.42 |
| Non-Neurologic PIM3 Risk of Mortality | 1.1 | 1.0-1.1 | <0.001 |
| Number of non-neurologic organ dysfunctions, Day 1 | |||
| None | Reference | ||
| 1 | 2.5 | 1.3-4.8 | 0.004 |
| 2 | 2.8 | 1.5-5.2 | 0.001 |
| More than 3 | 3.7 | 1.6-8.2 | 0.002 |
| Number of co-morbidities | |||
| None | Reference | ||
| 1 | 1.2 | 0.7-2.2 | 0.53 |
| More than 2 | 2.7 | 1.5-5.1 | 0.001 |
| Primary Site of Infection | |||
| Respiratory | Reference | ||
| Bloodstream | 1.2 | 0.7-2.0 | 0.59 |
| Central Nervous System | 2.0 | 0.7-5.5 | 0.18 |
| Other | 1.1 | 0.7-1.7 | 0.67 |
POPC = Pediatric Overall Performance Category, PIM = Pediatric Index of Mortality