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. 2022 Sep 30;18(9):e1010372. doi: 10.1371/journal.pgen.1010372

Fig 6. The SIX3/6 ortholog ceh-32 controls the identity of neurons in the anterior ganglion.

Fig 6

Fig 6A: In ceh-32(ok343) null mutant animals, OLL, URY but also RIA markers are almost always lost (ser-2prom3 otIs138, nlp-66(syb4403), eat-4prom8 otIs521). Fig 6B: ceh-32 also controls IL1 identity (flp-3 / otIs703 marked with white triangles), and affects neurons where it is not expressed in adults (IL2: klp-6 myIs13 marked with red triangles; OLQ: ttll-9 otIs849). Representative images of wild type and mutant worms are shown with 10 μm scale bars. Graphs compare expression in wild type and mutant worms with the number of animals examined listed at the bottom of the bar. P-values were calculated by Fisher’s exact test. Fig 6C: In ceh-32(ok343) and ceh-32(ot1242) null mutant animals, the GABAergic identity of all RME classes is affected (unc-25prom3del1 otIs837, unc-47 oxIs12, unc-46 fosmid otIs568). ceh-32 is expressed in adults in both RME and RIB, but ceh-32 loss did not affect RIB identity (unc-46 otIs568). Representative images of wild type and mutant worms are shown with 10 μm scale bars. Graphs compare expression in wild type and mutant worms with the number of animals examined listed at the bottom of the bar. P-values were calculated by Fisher’s exact test.