Table 1: Examples of current-generation drug-eluting stents and their physical properties.
BioFreedom/LUMENO Free | BioMatrix/Nobori | Orsiro | Promus PREMIER | Resolute Onyx | SYNERGY | Ultimaster | XIENCE Sierra | Xposition S | |
---|---|---|---|---|---|---|---|---|---|
Manufacturer | Biosensors/Cordis | Biosensors/Terumo | Biotronik | Boston Scientific | Medtronic | Boston Scientific | Terumo | Abbott | Stentys |
Design | |||||||||
Material | 316L SS* | 316L SS* | L605 CoCr† | PtCr‡ | MP35N CoCr§ (outer shell); PtIr core | PtCr‡ | L605 CoCr† | L605 CoCr† | NiTi (nitinol) |
Thickness of struts (μm) | 112 | 112 | 60–80 | 81–86 | 81 | 74–81 | 80 | 81 | 102–133 |
Polymer | Polymer-free | PLA | PLLA | PBMA, PVDF-HFP | BioLinx | 85:15 PLGA | PLCL | Fluoropolymer | |
Polymer degradation | Polymer-free | Bioresorbable | Bioresorbable | Permanent | Permanent | Bioresorbable | Bioresorbable | Permanent | Bioresorbable |
Polymer thickness (μm) | Polymer-free | 11 | 7.4 | 8 | 12 | 4 | 15 | 16 | – |
Drug | Biolimus A9 | Biolimus A9 | Everolimus | Everolimus | Zotarolimus | Everolimus | Sirolimus | Everolimus | Sirolimus |
*316L SS: 64% iron, 18% chromium, 14% nickel, 2.6% molybdenum, 2% (max) manganese.
†L605 CoCr: 52% cobalt, 20% chromium, 15% tungsten, 10% nickel, 3% (max) iron, 1.5% (max) manganese.
‡PtCr: 37% iron, 33% platinum, 18% chromium, 9% nickel, 2.6% molybdenum, 0.05% (max) manganese.
§MP35N CoCr: 35% nickel, 34% cobalt, 20% chromium 9.75% molybdenum, 1% (max) iron, 1% (max) titanium, 0.15% (max) manganese.
CoCr = cobalt–chromium; HFP = hexafluoropropylene; NiTi = nickel–titanium; PLA = polylactic acid; PLCL = poly (D,L-lactide-co-caprolactone); PLGA = poly(D,L-lactide-coglycolide); PLLA = poly-L-lactic acid; PBMA = poly (n-butyl methacrylate); PtCr = platinum–chromium; PtIr = platinum–iridium; PVDF = polyvinylidene fluoride; SS = stainless steel.