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. 2021 Dec 15;2(3):185–193. doi: 10.2478/rir-2021-0024

Figure 4.

Figure 4

TFH (CXCR5+ cell)-targeted NPs loaded with IL-2 limit the expansion of TFH cells in BDF1 lupus mice and reduce antibody production. (A) TFH cells (gated as in Figure 3A) at week 2 after treatment. BDF1 lupus mice were either left untreated or treated with untargeted NPs as controls, or received TFH-targeted NPs (IL-2-loaded). n = 8–11 mice per group; *P < 0.003; **P < 0.04. (B) Reduced antibody production in BDF1 lupus mice that received TFH-targeted NPs loaded with IL-2. Data are at week 4 after treatment. n = 4–6 per group; *P < 0.03; **P < 0.04; **P < 0.02. NPs, nanoparticles; TFH, T follicular helper.