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. 2022 Sep 16;16:978431. doi: 10.3389/fnins.2022.978431

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Copyright © 2022 Chen, Yi, Wang, Yuan, Wen, Li, Zou, Liu and Cai.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of high-fat diet on AMPK/mTOR/p70S6K pathway protein levels. Representative western blotting bands of mTOR, p-mTOR, AMPK, p-AMPK, and p70S6K in the hippocampus of the ND and HFD groups (shown in panel A). Statistical results showed that a high-fat diet increased p-mTOR levels and the p-mTOR/mTOR ratio, decreased p-AMPK levels and the p-AMPK/AMPK ratio and decreased p70S6K in the hippocampus (ND, n = 4 mice; HFD, n = 4 mice) (shown in panel B). BV2 cells treated with were done with PA medium (100 mM), and showed the same result (C,D) *p < 0.05, **p < 0.01.