Table 3.
Qualitative synthesis of efficacy.
| Outcome or subgroup | Studies | Participants | Statistical method | Effect estimate |
|---|---|---|---|---|
| 1.1ICU free (d) | 1 | 299 | Mean Difference (IV, Random, 95% CI) | 0.28 [−0.49, 1.02] |
| 1.2 ICU mortality | 1 | 277 | Odds Ratio (M-H, Fixed, 95% CI) | 0.51 [0.29, 0.89] |
| 1.3 Hospital mortality | 1 | 277 | Odds Ratio (M-H, Fixed, 95% CI) | 0.55 [0.32, 0.92] |
| 1.4 SOFA (mean, range) | 1 | 247 | Mean Difference (IV, Random, 95% CI) | −1.16 [−1.94, −0.38] |
| 1.5 SOFA (No. of patients) | 1 | 247 | Odds Ratio (M-H, Fixed, 95% CI) | 1.23 [0.68, 2.25] |
| 1.6 Peak airway pressure (cmH2O) | 1 | 88 | Mean Difference (IV, Random, 95% CI) | −1.00 [−2.40, 0.40] |
| 1.7 Arterial oxygen pressure (mm Hg) | 1 | 88 | Mean Difference (IV, Fixed, 95% CI) | 6.40 [4.41, 8.39] |
| 1.8 Days of PaO2 > 10kPa | 1 | 38 | Mean Difference (IV, Fixed, 95% CI) | −3.20 [−4.45, −1.95] |
| 1.9 PaO2 | 1 | 38 | Odds Ratio (M-H, Fixed, 95% CI) | 0.90 [−0.22, 2.02] |
ICU = intensive care unit, SOFA = sequential organ failure assessment, CI = confidence interval.