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. 2022 Sep 30;101(39):e30813. doi: 10.1097/MD.0000000000030813

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Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.

This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — Construction of the diagnostic snoRNA signature for HCC and identified key snoRNAs (A) least absolute shrinkage and selection operator (LASSO) coefficient profiles of the 42-survival related snoRNA. The tuning parameter (lambda) selection in the LASSO model. (B) The ROC curve of LASSO regression analysis. (C) The intersection diagram of 25 diagnostic model snoRNAs and 6 prognostic model snoRNAs. ROC curves for the SNORA11, SNORD124, SNORD46, SNORD63, SNORA59B in TCGA (D), ICGC (E). Key snoRNA expression level of SNORA11, SNORD124, SNORD46 in TCGA(F), ICGC (G). ****P < .0001. HCC = hepatocellular carcinoma, ICGC = international cancer genome consortium, ROC = receiver operating characteristic, snoRNAs = small nuclear RNAs, TCGA = the cancer genome atlas.