Table 3.
Subgroup of DFS with MTV and OS with MTV and TLG.
| Volumetric parameters | Factor | No. of studies | Heterogeneity test (I2, P) | Effect model | HR | 95%CI of HR | Conclusion |
|---|---|---|---|---|---|---|---|
| MTV | region | ||||||
| Asian | 5 | 21.3, .279 | fixed | 2.75 | 1.75,4.33 | significant | |
| Europen | 2 | 87.8, .004 | random | 1.76 | 0.55,5.65 | insignificant | |
| American | 3 | 94.5, .000 | random | 2.41 | 1.07,5.43 | significant | |
| Cutoff method | |||||||
| ROC | 4 | 0.0, .988 | fixed | 3.81 | 2.37,6.10 | significant | |
| Others | 6 | 87.0, .000 | random | 1.15 | 1.01,1.30 | significant | |
| Analysis method | |||||||
| Multivariate analysis | 5 | 91.3, .000 | random | 3.86 | 1.30,11.47 | significant | |
| Univariate analysis | 5 | 80.8, .000 | random | 1.57 | 0.98,2.51 | insignificant | |
| Endpoint | |||||||
| DFS | 4 | 78.1, .003 | random | 3.50 | 1.17,10.48 | significant | |
| RFS | 2 | 80.0, .026 | random | 1.71 | 0.52,5.68 | insignificant | |
| LFS | 2 | 0.0, .994 | fixed | 4.16 | 2.11,8.20 | significant | |
| EFS | 1 | - | - | 1.02 | 1.00,1.04 | insignificant | |
| PFS | 1 | - | - | 1.86 | 1.36,2.55 | significant | |
| MTV | region | ||||||
| Asian | 7 | 73.0, .001 | random | 1.96 | 1.16,3.31 | significant | |
| American | 3 | 93.3, .000 | random | 2.23 | 0.96,5.19 | insignificant | |
| European | 1 | - | - | 1.11 | 1.03,1.20 | significant | |
| Cutoff method | |||||||
| ROC | 4 | 72.0, .013 | random | 1.05 | 0.98,1.13 | insignificant | |
| Others | 7 | 83.3, .000 | random | 2.29 | 1.35,3.91 | significant | |
| Analysis method | |||||||
| Multivariate analysis | 4 | 0.0, .576 | fixed | 4.29 | 2.67,6.89 | significant | |
| Univariate analysis | 7 | 70.8, .002 | random | 1.09 | 1.01,1.17 | significant | |
| TLG | region | ||||||
| Asian | 4 | 74.1, .009 | random | 1.91 | 0.91，3.99 | insignificant | |
| European | 2 | 70.0, .068 | random | 2.02 | 0.88，4.66 | insignificant | |
| Cutoff method | |||||||
| ROC | 3 | 81.3, .005 | random | 1.88 | 0.74，4.79 | insignificant | |
| Others | 3 | 32.0, .230 | fixed | 1.67 | 1.20，2.31 | significant | |
| Analysis method | |||||||
| Multivariate analysis | 5 | 80.3, .000 | random | 1.77 | 1.09,2.88 | significant | |
| Univariate analysis | 1 | - | - | 2.61 | 0.84,8.09 | insignificant |
CI = confidence interval, DFS = disease-free survival, HR = hazard ratio, LFS = laryngectomy-free survival, MTV = metabolic tumor volume, PFS = progression-free survival, RFS = recurrence-free survival, ROC = receiver operating characteristic, TLG = total lesion glycolysis.