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Hematoxylin and eosin-stained (H&E) sections of tumor stroma percentage and TLS. (A) High TSP (>50%). (B) Low TSP (≤50%). Germinal centers (GCs) were confirmed to contain strictly confined regions of CD21 follicular dendritic cells in a field of larger CD23 and Ki67 B cells (CD20) surrounded by PNAd vessels (C–I). Peri-tumor region was surrounded in red while intra-tumor region was surrounded in brown (J). In-TLS (K) and P-TLS (L) are highlighted in blue and red, respectively.
