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. 2022 Sep 16;13:962056. doi: 10.3389/fimmu.2022.962056

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Copyright © 2022 Wang, Shen, An, Bai, Dong, Cai, Zhu, Zhong, Chen, Liu and Du

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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TLS in nmCRC. (A) The mucosal TLSs were almost squished and elongated or teardrop-shaped; (B, C) the submucosal and basal lamina propria TLSs were usually oval-shape; (D) CD4+ T cells; (E) CD8+ T cells; (F) CD45RO+ lymphocytes; (G) CD11c+DC cells; (H) CD68+ TAMs; (I) FOXP3+ Tregs; (J) NCR1+ NK cells; (K) CD15+ TANs.