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. 2022 Sep 16;13:962056. doi: 10.3389/fimmu.2022.962056

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Copyright © 2022 Wang, Shen, An, Bai, Dong, Cai, Zhu, Zhong, Chen, Liu and Du

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Relationship between the P-TLS and TSP and prognosis of nmCRC in the training set. (A) ROC curve of P-TLS density and patient prognosis. The optimum cut-off is 0.098, and when using this point for segmentation, the sensitivity is 0.805 and the specificity is 0.704. Association of the P-TLS density with RFS (B) and OS (C), and TNM I-II (D, E) and III (F, G) CRC patients. Association of the P-TLS maturation stage with RFS (H) and OS (I). Association of the TSP with RFS (J) and OS (K). Kaplan-Meier survival analyses for RFS (L) and OS (M) were performed according to group 1, group 2, and group 3. Group 1: TLS^hiTSP^lo group, group 2: TLS^hiTSP^hi or TLS^loTSP^lo group, and group 3: the TLS^loTSP^hi group.