Table 1.
Demographics and clinical characteristics of nmCRC patients.
| Characteristics | Training set n (%) | External validation set n (%) | P value |
|---|---|---|---|
| Sex | 0.6280 | ||
| Male | 65 (57.0) | 37 (61.7) | |
| Female | 49 (43.0) | 23 (38.3) | |
| Age(years) | 0.0774 | ||
| >60 | 41 (36.0) | 30 (50.0) | |
| ≤60 | 73 (64.0) | 30 (50.0) | |
| Location | 0.6240 | ||
| Rectum | 75 (65.8) | 35 (58.3) | |
| Left colon | 19 (16.7) | 12 (20.0) | |
| Right colon | 20 (17.5) | 13 (21.7) | |
| Lymph node-positive | >0.9999 | ||
| YES | 47 (41.2) | 25 (41.7) | |
| NO | 67 (58.8) | 35 (58.3) | |
| Perineural invasion | 0.8425 | ||
| YES | 23 (20.2) | 11 (18.3) | |
| NO | 91 (79.8) | 49 (81.7) | |
| Vascular invasion | 0.6774 | ||
| YES | 19 (16.7) | 12 (20.0) | |
| NO | 95 (83.3) | 48 (80.0) | |
| T stage | 0.8991 | ||
| T1 | 7 (6.1) | 5 (8.3) | |
| T2 | 15 (13.2) | 7 (11.7) | |
| T3 | 83 (72.8) | 42 (70.0) | |
| T4 | 9 (7.9) | 6 (10.0) | |
| N stage | 0.7808 | ||
| N0 | 67 (58.8) | 35 (58.3) | |
| N1 | 30 (26.3) | 18 (30.0) | |
| N2 | 17 (14.9) | 7 (11.7) | |
| TNM stage* | 0.9063 | ||
| I | 22 (19.3) | 10 (16.7) | |
| II | 45 (39.5) | 25 (41.7) | |
| III | 47 (41.2) | 25 (41.7) | |
| Tumor grade | 0.5119 | ||
| G1 | 27 (23.7) | 11 (18.3) | |
| G2 | 74 (64.9) | 39 (65.0) | |
| G3 | 13 (11.4) | 10 (16.7) | |
| MMR | 0.8247 | ||
| dMMR | 17 (14.9) | 8 (13.3) | |
| pMMR | 97 (85.1) | 52 (86.7) | |
| TSP | >0.9999 | ||
| H-TSP | 47 (41.2) | 24 (40.0) | |
| L-TSP | 67 (58.8) | 36 (60.0) | |
| P-TLS density (median) | 0.1535 | 0.1555 | 0.7266 |
| P-TLSmaturation stages | 0.5476 | ||
| E-TLS | 25 (22.1) | 9 (15.3) | |
| PFL-TLS | 51 (45.1) | 28 (47.5) | |
| SFL-TLS | 37 (32.7) | 22 (37.3) |
nmCRC, non-metastatic colorectal cancer; MMR, mismatch repair; P-TLS, peritumoral tertiary lymphoid structure; E-TLS, early -TLS; TSP, PFL-TLS, primary follicle-like -TLS; SFL-TLS, secondary follicle-like -TLS; TSP, tumor stroma percentage. *The 8th AJCC TNM staging system