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(A) Role of Ontogeny in Kotb Disease BA variant. Time line during the first, second and third months of life respectively. CYP 450 = cytochrome P450 family, others = glucuronidation. They have different expression levels and reach maturation at different ages within days, weeks, and years from birth.53 (B) Interaction of aflatoxins, host factors, timing and immune response in the liver in the Kotb Disease BA variant. GST = glutathione S-transferase.
